Functional Nanorealgar Quantum Dots with Aggregation-Induced Emission Enhancement for Tumor Neovascular-Targeted Theranostics

Realgar, a traditional Chinese medicine, has notable antitumor activity and can be used in various hematologic tumor solid therapies wide range of clinical applications. Nanosized realgar possesses higher surface enhanced therapeutic effects on cancer cells compared with those bulk realgar. In this study, we reported the design high-performance nanorealgar quantum dots (NR QDs) aggregation-induced emission enhancement crystal units (CUs) addition hydrochloric acid. The fluorescence characteristics NR QDs are associated an optimized structure obtained by accelerating growth process CUs which smaller facilitate self-assembling arrangement complete structural optimization process, ultimately forming regular crystallization size quantization effect. To improve theranostic efficiency QDs, synthesized coupled tripeptide arginine–glycine–aspartic acid (RGD) neovascular targeting. We intravenously injected NR@RGD into BALB/c mice bearing subcutaneously transplanted breast (4T1). Our results indicate that functional effective chemotherapeutic drugs anchor endothelial through active targeting effect, inhibit angiogenesis tumor, eventually “cut-off” nutrient-rich blood supply to tumor. This promising antiangiogenesis strategy induces penetrate tumor-fenestrated vascular networks potential value.